I don't know if this is true for other people, but I am still experiencing at least some of the problems described here and here, namely that Chrome crashes when I try to write answers that are too long. This also happens to me on MO sometimes.
This is annoying but not too bad when I'm writing an answer for the first time (I can usually recover the answer using the back button, but the longer the answer gets the more likely Chrome is to crash again), but when I'm editing an answer I lose all of my work when this happens. Also, even when I don't lose all my work while editing, there is a lot of lag.
I'm using Chrome with several extensions, but I generally don't have many tabs open at one time; maybe 3 or 4.
Edit (10/31/12): This remains an issue and remains annoying.
Edit (11/10/12): The situation has gotten a little worse. Chrome is now freezing instead of crashing.