For a site whole purpose in life is to allow people to ask questions and answer them, the new design does not make the two corresponding 'links' prominent at all!
Moreover, I really think it is quite not apparent that the "QUESTIONS TAGS USERS..." thingies under the header are active (you can hover over them, and then the thin font with which by browser renders then becomes #90191C: this is too subtle IMHO. Before it was way more obvious that something would happen upon clicking them: now, they look like a subtitle, specially because they match the all-caps style of the header (I guess one cannot assume real small caps are available?)
The votes/answer counts are horizontally distributed in the parent site and vertically distributed on the meta site, but this seems to change every few reloads. The effect is weird :) The ayout is vertical but different in the QUESTIONS and UNANSWERED pages.
Can it be ASK A QUESTION?
I support making "ask question" a different color.
It's sort of a myth in the Q&A world that you want to make it so easy for newbies to ask questions. This logic leads directly to things like http://yahooanswerfail.com
What you do want to do is make it easy for people to browse around -- and they have to work a teeny-tiny bit to find out how to ask. If they're not willing to put in the tiniest amount of work, the odds of that user asking a question you as an expert would want to answer is vanishingly small.